Podocyte injury underlies the progression of focal segmental glomerulosclerosis in the fa/fa Zucker rat
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چکیده
منابع مشابه
Secondary Focal Segmental Glomerulosclerosis: From Podocyte Injury to Glomerulosclerosis
Focal segmental glomerulosclerosis (FSGS) is a common cause of proteinuria and nephrotic syndrome leading to end stage renal disease (ESRD). There are two types of FSGS, primary (idiopathic) and secondary forms. Secondary FSGS shows less severe clinical features compared to those of the primary one. However, secondary FSGS has an important clinical significance because a variety of renal diseas...
متن کاملMoxibustion Alleviates Injury in a Rat Focal Segmental Glomerulosclerosis Model
OBJECTIVES To evaluate the therapeutic effects of moxibustion at Shenshu (BL-23) and Geshu (BL-17) acupoints in a focal segmental glomerulosclerosis (FSGS) model in rats. METHODS A FSGS rat model was established by single nephrectomy and repeated injection of doxorubicin. The FSGS rats were randomly divided into the model group, losartan (positive control) group, Shenshu moxibustion group, an...
متن کاملGenetic testing for podocyte genes in sporadic focal segmental glomerulosclerosis.
Focal segmental glomerulosclerosis (FSGS) is a clinicopathological entity that manifests with severe proteinuria and/or nephrotic syndrome. FSGS is considered to represent a pattern of glomerular scarring, rather than a specific disease entity. The histological hallmark of FSGS is characterized by sclerosis that involves some, but not all, glomeruli and the affected glomeruli typically show inv...
متن کاملPodocyte-specific RAP1GAP expression contributes to focal segmental glomerulosclerosis-associated glomerular injury.
Injury to the specialized epithelial cells of the glomerulus (podocytes) underlies the pathogenesis of all forms of proteinuric kidney disease; however, the specific genetic changes that mediate podocyte dysfunction after injury are not fully understood. Here, we performed a large-scale insertional mutagenic screen of injury-resistant podocytes isolated from mice and found that increased expres...
متن کاملA multicolor podocyte reporter highlights heterogeneous podocyte changes in focal segmental glomerulosclerosis
In contrast to most glomerular diseases, the injury pattern in focal segmental glomerulosclerosis (FSGS) is highly heterogeneous, even though podocytes are genetically identical and exposed to the same environmental factors. To understand changes in individual podocytes, we generated and analyzed a stochastic multicolor Cre-reporter, encoding four fluorescent proteins. In these animals, podocyt...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2001
ISSN: 0085-2538
DOI: 10.1046/j.1523-1755.2001.00777.x